Clotting factor V activity in plasma cryoproteins

High Factor V Clotting Activity Is an Independent Risk Factor for Myocardial Infarction

Increased levels of hemostatic factors and genetic mutations of proteins involved in coagulation may play a role in the pathogenesis of coronary artery disease. We investigated clotting activity of factors II (FII:C), V (FV:C), VII (FVII:C), and X (FX:C), the prothrombin gene 20210G3A transition, and the factor V Leiden mutation in 200 survivors of myocardial infarction and in 100 healthy contr...

Hereditary plasma clotting factor disorders and their management.

Thrombin clotting activity measurement and standardization with lyophilized plasma.

Thrombin-induced clotting times were inversely proportional to fibrinogen concentrations within the range of 98 to 2900 nmol/L; these reciprocal velocity measurements had units of seconds per clot. By analogy with classical enzyme kinetics, we defined rectangular hyperbolic parameters where Km(clot) ranged from 0.14 to 0.56 mumol/L and kclot from 0.020 to 0.075 clot per second. Specificity rati...

FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...

Fitzgerald Factor ( High Molecular Weight Kininogen ) Clotting Activity in Human Plasma in Health and Disease in Various Animal Plasm

Fitzgerald factor ( high molecular weight kininogen) is an agent in normal human plasma that corrects the impaired in vitro surface-mediated plasma reactions of blood coagulation, fibrinolysis, and kinin generation observed in Fitzgerald trait plasma. To assess the possible pathophysiologic role of Fitzgerald factor, its titer was measured by a functional clot-promoting assay. Mean ± SD in 42 n...